Max S R, Rance N E
J Appl Physiol Respir Environ Exerc Physiol. 1984 Jun;56(6):1589-93. doi: 10.1152/jappl.1984.56.6.1589.
We studied the effects of sex steroids on muscle weight and oxidative capacity of rat plantaris muscles subjected to functional overload by removal of synergistic muscles. Eight weeks after bilateral synergist removal, plantaris muscles were strikingly hypertrophic compared with unoperated controls. After this period, there were selective alterations in the ability of the muscles to oxidize three substrates of oxidative metabolism. Thus 14CO2 production from [6-14C]glucose and [2-14C]pyruvate was significantly reduced, whereas there was no alteration in 14CO2 production from beta-[3-14C]hydroxybutyrate. Succinate dehydrogenase specific activity was decreased in overloaded muscle. There was no effect of sex hormone status on any of these parameters. Finally, 30 days of functional overload did not influence cytosolic androgen receptor binding. These results are not consistent with the idea that sex steroids and functional overload act synergistically.
我们研究了性类固醇对通过切除协同肌而承受功能过载的大鼠跖肌肌肉重量和氧化能力的影响。双侧协同肌切除八周后，与未手术的对照组相比，跖肌明显肥大。在此之后，肌肉氧化三种氧化代谢底物的能力发生了选择性改变。因此，[6-¹⁴C]葡萄糖和[2-¹⁴C]丙酮酸产生¹⁴CO₂的量显著减少，而β-[3-¹⁴C]羟基丁酸产生¹⁴CO₂的量没有变化。过载肌肉中琥珀酸脱氢酶的比活性降低。性激素状态对这些参数中的任何一个都没有影响。最后，30天的功能过载并未影响细胞溶质雄激素受体结合。这些结果与性类固醇和功能过载协同作用的观点不一致。
