Lebaron S, Zeltzer L
J Adolesc Health Care. 1984 Jul;5(3):178-82. doi: 10.1016/s0197-0070(84)80039-x.
Eight adolescents (10-17 years, mean 12.1) with cancer received behavioral intervention for chemotherapy-related nausea and vomiting. Within 3-5 days after the administration of each course of chemotherapy, patients rated (1-10 scale; 1 = none, 10 = maximum) their nausea and vomiting and the extent to which chemotherapy bothered them and disrupted their daily routine. After a baseline (preintervention) assessment of 2-3 courses of chemotherapy, patients received intervention during another 2-3 courses. While no significant reduction of symptoms were found prior to intervention, with intervention there were reductions in nausea (Z = 2.37, p less than 0.02), vomiting (Z = 2.52, p less than 0.01), bother (Z = 2.24, p less than 0.02), and disruption of activities (Z = 2.38, p less than 0.02). This preliminary study suggests that chemotherapy side effects in adolescents can be reduced with behavioral intervention.
八名患有癌症的青少年（年龄在10至17岁之间，平均年龄12.1岁）接受了针对化疗相关恶心和呕吐的行为干预。在每疗程化疗给药后的3至5天内，患者对自己的恶心和呕吐情况以及化疗对他们的困扰程度和对日常生活的干扰程度进行评分（1至10分制；1分表示无，10分表示最严重）。在对2至3个疗程的化疗进行基线（干预前）评估后，患者在另外2至3个疗程中接受干预。虽然在干预前未发现症状有显著减轻，但在干预后，恶心（Z = 2.37，p < 0.02）、呕吐（Z = 2.52，p < 0.01）、困扰程度（Z = 2.24，p < 0.02）和活动干扰（Z = 2.38，p < 0.02）均有所减轻。这项初步研究表明，行为干预可以减轻青少年化疗的副作用。
