Studies of 7 beta-[2-(aminoaryl)acetamido]-cephalosporin derivatives. I. Synthesis and structure-activity relationships in the aminopyridine series.
作者信息
Goto J, Sakane K, Nakai Y, Teraji T, Kamiya T
出版信息
J Antibiot (Tokyo). 1984 May;37(5):532-45. doi: 10.7164/antibiotics.37.532.
PMID:6735926
Abstract
The synthesis and in vitro activity of 7 beta-(2-aminopyridyl-2-alkoxyiminoacetamido)cephalosporins with various substituents at the 3-position are described. The effects of substitution pattern on the pyridine ring, oxime substituent and 3-substituent were studied as a function of the MIC values. Of these various kinds of derivatives, 7 beta-[2-(2-aminopyridin-6-yl)-2-alkoxyiminoacetamido]cephalo sporins exhibited significantly higher activity against most of micro-organisms.
摘要
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