7β-[2-(氨基芳基)乙酰胺基]-头孢菌素衍生物的研究。III. 氨基噻二唑系列的合成与构效关系
Studies of 7 beta-[2-(aminoaryl)acetamido]-cephalosporin derivatives. III. Synthesis and structure-activity relationships in the aminothiadiazole series.
作者信息
Goto J, Sakane K, Teraji T
出版信息
J Antibiot (Tokyo). 1984 May;37(5):557-71. doi: 10.7164/antibiotics.37.557.
PMID:6735928
Abstract
The synthesis and in vitro antibacterial activity of 7 beta-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxyiminoacetamido] cephalosporins with various substituents at the 3-position in the cephem nucleus are described. Aminothiadiazolyl cephalosporins having pyridiniomethyl groups at the 3-position exhibited excellent activity against all organisms, particularly against Pseudomonas aeruginosa.
摘要
描述了在头孢烯核3-位带有不同取代基的7β-[2-(5-氨基-1,2,4-噻二唑-3-基)-2-氧亚氨基乙酰胺基]头孢菌素的合成及其体外抗菌活性。在3-位带有吡啶甲基的氨基噻二唑基头孢菌素对所有菌株均表现出优异的活性，尤其对铜绿假单胞菌。
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