Davidson J, Turnbull C
J Clin Psychiatry. 1984 Jul;45(7 Pt 2):49-52.
Little information is available on the effectiveness and safety of particular doses of isocarboxazid. In a study using isocarboxazid doses of 30 and 50 mg/day in depressed inpatients, the higher dose was well tolerated and did not result in any greater toxicity than the 30 mg dose. Significantly greater elevation of plasma serotonin (Week 2) and platelet MAO inhibition were seen with 50 mg/day. In nonmelancholic depressions, 50 mg proved to be more effective than 30 mg in symptoms of depression and anxiety. However, this did not apply to the vegetative-physiologic symptoms of depression.
关于特定剂量异卡波肼的有效性和安全性，可获取的信息较少。在一项针对抑郁症住院患者使用30毫克/天和50毫克/天异卡波肼剂量的研究中，较高剂量耐受性良好，且未产生比30毫克剂量更大的毒性。每天50毫克剂量时，血浆血清素水平显著升高（第2周），血小板单胺氧化酶抑制作用更强。在非忧郁性抑郁症中，50毫克剂量在抑郁和焦虑症状方面比30毫克剂量更有效。然而，这不适用于抑郁症的植物神经生理症状。
