小鼠实体瘤对造血骨髓细胞增殖动力学的影响。
The influence of a solid tumor of the mouse on the proliferation kinetics of haemopoietic bone marrow cells.
作者信息
Féaux de Lacroix W, Buran-Kilian B
出版信息
J Cancer Res Clin Oncol. 1984;107(3):164-8. doi: 10.1007/BF01032601.
Abstract
It is generally accepted that cancer has strong effects on bone marrow cells (e.g. tumor-associated anaemia). The present investigation studies the proliferation kinetics of haemopoietic cells and the topographic differences in proliferation patterns in the bone marrow of tumor-bearing animals and controls. It was demonstrated that the differences in the cell cycle times, whether between peripheral and central parts of the bone marrow or between the experimental group and the control group, were slight or nonexistent. However, the growth fraction showed an increased proliferation rate in tumor-bearing as compared with normal animals (57% and 37%, respectively).
摘要
人们普遍认为癌症对骨髓细胞有显著影响（如肿瘤相关性贫血）。本研究调查了荷瘤动物和对照组动物骨髓中造血细胞的增殖动力学以及增殖模式的地形差异。结果表明，无论是骨髓外周与中央部分之间，还是实验组与对照组之间，细胞周期时间的差异都很小或不存在。然而，与正常动物相比，荷瘤动物的生长分数显示出增殖率增加（分别为57%和37%）。
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