采用高效液相色谱法对马血浆和尿液中的四种愈创甘油醚葡糖苷酸进行分离、部分鉴定和定量测定。
Isolation, partial identification and quantitative determination of four guaiphenesin glucuronides in plasma and urine of the horse by high-performance liquid chromatography.
作者信息
Ketelaars H C, Peters J G, Anzion R B, Van Ginneken C A
出版信息
J Chromatogr. 1984 Apr 24;288(2):423-9. doi: 10.1016/s0021-9673(01)93718-5.
PMID:6736150
Abstract
The isolation, partial identification and quantitative determination of four guaiphenesin glucuronides in plasma and urine of the horse is described. The identity of the glucuronides was checked by UV and fluorescence spectrophotometry, by NMR spectrometry and by mass spectrometry after permethylation. The applicability of the procedure to pharmacokinetic studies is demonstrated.
摘要
本文描述了马血浆和尿液中四种愈创甘油醚葡糖醛酸苷的分离、部分鉴定和定量测定。通过紫外和荧光分光光度法、核磁共振光谱法以及全甲基化后的质谱法对葡糖醛酸苷的身份进行了验证。证明了该方法在药代动力学研究中的适用性。
相似文献
1
Isolation, partial identification and quantitative determination of four guaiphenesin glucuronides in plasma and urine of the horse by high-performance liquid chromatography.采用高效液相色谱法对马血浆和尿液中的四种愈创甘油醚葡糖苷酸进行分离、部分鉴定和定量测定。
J Chromatogr. 1984 Apr 24;288(2):423-9. doi: 10.1016/s0021-9673(01)93718-5.
2
Simultaneous determination of theophylline and guaiphenesin by third-derivative ultraviolet spectrophotometry and high-performance liquid chromatography.用三阶导数紫外分光光度法和高效液相色谱法同时测定茶碱和愈创甘油醚。
Analyst. 1992 Feb;117(2):157-60. doi: 10.1039/an9921700157.
3
Determination of guaiphenesin and its metabolite, beta-(2-methoxyphenoxy)-lactic acid, in plasma by high-performance liquid chromatography.高效液相色谱法测定血浆中愈创甘油醚及其代谢物β-(2-甲氧基苯氧基)-乳酸
J Chromatogr. 1981 Jun 12;224(1):144-8. doi: 10.1016/s0378-4347(00)80149-8.
4
Direct high-performance liquid chromatography determination of propofol and its metabolite quinol with their glucuronide conjugates and preliminary pharmacokinetics in plasma and urine of man.直接高效液相色谱法测定丙泊酚及其代谢产物喹诺酚及其葡萄糖醛酸结合物，并对人体血浆和尿液进行初步药代动力学研究。
J Chromatogr B Biomed Sci Appl. 1999 Jan 22;721(2):217-28. doi: 10.1016/s0378-4347(98)00466-6.
5
Determination of amiodarone and desethylamiodarone in horse plasma and urine by high-performance liquid chromatography combined with UV detection and electrospray ionization mass spectrometry.高效液相色谱结合紫外检测和电喷雾电离质谱法测定马血浆和尿液中的胺碘酮和去乙基胺碘酮。
J Chromatogr B Analyt Technol Biomed Life Sci. 2006 May 19;836(1-2):47-56. doi: 10.1016/j.jchromb.2006.03.038. Epub 2006 Apr 17.
6
Separation, isolation and identification of optical isomers of 1,4-benzodiazepine glucuronides from biological fluids by reversed-phase high-performance liquid chromatography.
J Chromatogr. 1984 Mar 9;306:231-9. doi: 10.1016/s0378-4347(00)80885-3.
7
On-line identification of tropane alkaloids from Erythroxylum vacciniifolium by liquid chromatography-UV detection-multiple mass spectrometry and liquid chromatography-nuclear magnetic resonance spectrometry.采用液相色谱-紫外检测-串联质谱法和液相色谱-核磁共振光谱法在线鉴定越橘叶古柯中的托烷生物碱。
J Chromatogr A. 2003 Dec 5;1020(1):75-89. doi: 10.1016/j.chroma.2003.08.052.
8
Identification of the glucuronides of the hydroxylated metabolites of the antimalarial arteether in rat plasma and urine by thermospray high-performance liquid chromatography/mass spectrometry.采用热喷雾高效液相色谱/质谱法鉴定大鼠血浆和尿液中抗疟药蒿甲醚羟基化代谢物的葡糖醛酸苷。
J Pharm Sci. 1997 Aug;86(8):915-20. doi: 10.1021/js960424k.
9
Identification and quantification of metabolites of 2,3,5,6-tetrafluoro-4-trifluoromethylaniline in rat urine using 19F nuclear magnetic resonance spectroscopy, high-performance liquid chromatography-nuclear magnetic resonance spectroscopy and high-performance liquid chromatography-mass spectrometry.使用¹⁹F核磁共振光谱、高效液相色谱-核磁共振光谱和高效液相色谱-质谱法鉴定和定量大鼠尿液中2,3,5,6-四氟-4-三氟甲基苯胺的代谢产物。
J Chromatogr B Biomed Sci Appl. 2000 Oct 1;748(1):311-9. doi: 10.1016/s0378-4347(00)00321-2.
10
Identification and quantitation of intact diastereoisomeric benzodiazepine glucuronides in biological samples by high-performance liquid chromatography.通过高效液相色谱法对生物样品中完整的非对映异构苯二氮䓬葡萄糖醛酸苷进行鉴定和定量分析。
J Chromatogr. 1993 Mar 5;613(1):162-7. doi: 10.1016/0378-4347(93)80211-l.
Zotero 插件