Ketelaars H C, Peters J G, Anzion R B, Van Ginneken C A
J Chromatogr. 1984 Apr 24;288(2):423-9. doi: 10.1016/s0021-9673(01)93718-5.
The isolation, partial identification and quantitative determination of four guaiphenesin glucuronides in plasma and urine of the horse is described. The identity of the glucuronides was checked by UV and fluorescence spectrophotometry, by NMR spectrometry and by mass spectrometry after permethylation. The applicability of the procedure to pharmacokinetic studies is demonstrated.
本文描述了马血浆和尿液中四种愈创甘油醚葡糖醛酸苷的分离、部分鉴定和定量测定。通过紫外和荧光分光光度法、核磁共振光谱法以及全甲基化后的质谱法对葡糖醛酸苷的身份进行了验证。证明了该方法在药代动力学研究中的适用性。
