Celada A, Stray S, Sivarajan M, Finch C
J Clin Invest. 1984 Jul;74(1):161-4. doi: 10.1172/JCI111396.
Marrow radioiron uptake and marrow blood flow were measured in order to evaluate iron supply for erythropoiesis. Normal, phenylhydrazine-treated and bled animals were studied. The plasma iron turnover of seven normal rabbits was 1.49 +/- 0.22 mg/dl whole blood per d, of 11 rabbits treated 4 d before with phenylhydrazine was 5.16 +/- 1.81, and of four bled animals the plasma iron turnover was 3.75 +/- 1.61. The cardiac output and the percentage of blood flow to the marrow was increased in phenylhydrazine-treated and bled animals. Marrow iron flow in phenylhydrazine-treated animals was 38.3 +/- 32.6 micrograms/min per kg as compared with control values of 7.0 +/- 1.3 (P less than 0.01). This was due to an increase in marrow flow, an increase in plasma iron, and an increase in plasmatocrit. In bled animals, in spite of an increased marrow blood flow, marrow iron flow of 7.3 +/- 2.2 was similar to that of control animals due to a lower plasma iron concentration. The calculated marrow iron extraction of 3.7 +/- 2.4% in phenylhydrazine-treated animals was not different from that of control animals of 4.3 +/- 1.1, whereas extraction was increased in bled animals to 7.9 +/- 1.3 (P less than 0.01). In additional studies of transfused animals, acutely induced anemia was associated with an increased cardiac output, but also with a relative decrease in marrow flow, which left marrow iron supply unaffected. It would appear from these studies that an important mechanism for meeting the increased iron requirement of the hyperplastic erythroid marrow is an increase in marrow blood flow.
为评估红细胞生成的铁供应情况，对骨髓放射性铁摄取量和骨髓血流量进行了测量。研究对象包括正常动物、经苯肼处理的动物和放血动物。7只正常兔子的血浆铁周转率为每天每分升全血1.49±0.22毫克，11只在4天前接受苯肼处理的兔子的血浆铁周转率为5.16±1.81，4只放血动物的血浆铁周转率为3.75±1.61。经苯肼处理的动物和放血动物的心输出量及流向骨髓的血流量百分比均增加。经苯肼处理的动物的骨髓铁流量为每千克每分钟38.3±32.6微克，而对照值为7.0±1.3（P<0.01）。这是由于骨髓血流量增加、血浆铁增加以及血细胞比容增加所致。在放血动物中，尽管骨髓血流量增加，但由于血浆铁浓度较低，骨髓铁流量为7.3±2.2，与对照动物相似。经苯肼处理的动物计算得出的骨髓铁摄取率为3.7±2.4%，与对照动物的4.3±1.1%无差异，而放血动物的摄取率增加至7.9±1.3（P<0.01）。在对输血动物的进一步研究中，急性诱导的贫血与心输出量增加有关，但也与骨髓血流量相对减少有关，这使得骨髓铁供应未受影响。从这些研究看来，满足增生性红系骨髓增加的铁需求的一个重要机制是骨髓血流量增加。
