Feldman B F, Kaneko J J, Farver T B
Am J Vet Res. 1981 Apr;42(4):583-5.
Anemia of inflammatory disease induced by injection of adjuvant was characterized by decreases in hematocrit (mean +/- 1 SD, 37.5 +/- 2.7%, as compared with base-line values of 49.8 +/- 2.4%) and hemoglobin (12.54 +/- 1.22 g/dl, as compared with base line of 16.87 +/- 0.96 g/dl) and was classified as unresponsive, normocytic, and normochromic. Disordered iron metabolism was manifest by decreases in serum iron (62.3 +/- 13.6 g/dl, as compared with base line or 113.0 +/- 8.2 g/dl) and shortened mean radioiron clearance half-times (50.0 +/- 12.6 minutes, as compared with base line of 74.0 +/- 13.6 minutes) in the presence of increased bone marrow reticuloendothelial iron. Shortened radioiron clearance half-times reflected maximal extraction of iron from the plasma by the erythroid marrow due to suboptimal iron supply, since extraction of iron by other tissues is minor. Shortened mean marrow transit times (2.79 +/- 0.46 days, as compared with base line of 5.4 +/- 0.64 days) were indicative of adequate erythropoietin stimulation in the anemia of inflammatory disease. Increases in plasma iron turnover rate over base line (1.73 +/- 0.33 mg/dl/day to 1.51 +/- 0.34 mg/dl/day), erythron iron turnover rate (1.50 +/- 0.27 mg/dl/day, as compared with base line of 0.99 +/- 0.27 mg/dl/day), and RBC iron utilization (86 +/- 8.3%, as compared with base-line utilization of 65 +/- 9.3%) indicated erythroid marrow proliferation was effective. The magnitude of erythroid response appeared to be limited mainly by iron supply.
注射佐剂诱导的炎症性疾病贫血的特征为血细胞比容降低（均值±1标准差，37.5±2.7%，而基线值为49.8±2.4%）和血红蛋白降低（12.54±1.22 g/dl，而基线值为16.87±0.96 g/dl），并被分类为无反应性、正细胞性和正色素性。铁代谢紊乱表现为血清铁降低（62.3±13.6 g/dl，而基线值为113.0±8.2 g/dl）以及在骨髓网状内皮铁增加的情况下平均放射性铁清除半衰期缩短（50.0±12.6分钟，而基线值为74.0±13.6分钟）。放射性铁清除半衰期缩短反映了由于铁供应不足，红系骨髓从血浆中最大程度地摄取铁，因为其他组织摄取的铁较少。平均骨髓转运时间缩短（2.79±0.46天，而基线值为5.4±0.64天）表明炎症性疾病贫血中有足够的促红细胞生成素刺激。血浆铁周转率相对于基线增加（从1.73±0.33 mg/dl/天增至1.51±0.34 mg/dl/天）、红系铁周转率（1.50±0.27 mg/dl/天，而基线值为0.99±0.27 mg/dl/天）以及红细胞铁利用率增加（86±8.3%，而基线利用率为65±9.3%）表明红系骨髓增殖有效。红系反应的程度似乎主要受铁供应的限制。
