三氯甲苯异构体的毒性：在大鼠中进行的为期28天的喂养研究。

Toxicity of trichlorotoluene isomers: a 28-day feeding study in the rat.

作者信息

Chu I, Shen S Y, Villeneuve D C, Secours V E, Valli V E

出版信息

J Environ Sci Health B. 1984 Mar;19(2):183-91. doi: 10.1080/03601238409372424.

Abstract

Groups of 10 male and 10 female rats were fed alpha,alpha,alpha-, alpha,2,6- or 2,3,6- trichlorotoluene (TCT) in their diet at 0, 0.5, 5.0, 50 or 500 ppm for 28 days. Growth rate and food consumption were not affected by treatment. No deaths occurred. Significant increases in liver weights were observed in male rats fed 5.0 and 500 ppm 2,3,6-TCT. Mild serum biochemical changes occurred in male rats. These included increased SDH activities in the groups fed 5.0 and 50 ppm alpha, alpha, alpha-TCT, and 5.0 ppm 2,3,6-TCT. Alpha, alpha, alpha-TCT at 500 ppm caused elevated LDH activities in male rats. Hepatic microsomal aminopyrine N-demethylase activities were increased in male rats fed 500 ppm alpha,2,6-TCT. Hematological parameters were not affected by treatment. Mild histological changes were seen in the liver, kidney and thyroid of treated rats. Data presented here suggest that alpha, alpha, alpha-, alpha,2,6- and 2,3,6-TCT possess a low order of oral toxicity in the rat.

摘要

将10只雄性和10只雌性大鼠分为几组，在其饮食中分别添加0、0.5、5.0、50或500 ppm的α,α,α-、α,2,6-或2,3,6-三氯甲苯（TCT），持续28天。生长速率和食物摄入量不受处理的影响。没有死亡发生。在喂食5.0和500 ppm 2,3,6-TCT的雄性大鼠中观察到肝脏重量显著增加。雄性大鼠出现了轻微的血清生化变化。这些变化包括在喂食5.0和50 ppm α,α,α-TCT以及5.0 ppm 2,3,6-TCT的组中，SDH活性增加。500 ppm的α,α,α-TCT导致雄性大鼠LDH活性升高。喂食500 ppm α,2,6-TCT的雄性大鼠肝微粒体氨基比林N-脱甲基酶活性增加。血液学参数不受处理的影响。在处理过的大鼠的肝脏、肾脏和甲状腺中观察到轻微的组织学变化。此处呈现的数据表明，α,α,α-、α,2,6-和2,3,6-TCT对大鼠的口服毒性较低。