Chu I, Secours V E, Villeneuve D C, Valli V E
J Toxicol Environ Health. 1982 Aug;10(2):285-96. doi: 10.1080/15287398209530251.
This study was designed to investigate the acute and subacute toxicity of octachlorostyrene (OCS), a demonstrated environmental pollutant in fish from the Great Lakes and off the Norwegian coast in Europe. In an acute study, groups of 10 male rats were given by gavage single doses of OCS at 1300, 1690, 2190, 2850, or 3710 mg/kg and killed 14 d later. Octachlorostyrene at a dose of 1690 mg/kg and higher caused increased liver weight, increased hepatic microsomal aniline hydroxylase and aminopyrine demethylase activities, and increased serum cholesterol and uric acid levels. Only mild histological changes were seen in the thyroid of the treated animals. In a subacute study, groups of 10 male and female rats were fed diets containing 0.5, 5.0, 50 or 500 ppm OCS for 28 d. Growth rate and food consumption were not affected by treatment. Liver hypertrophy and hepatic microsomal enzyme induction were observed in animals fed 50 ppm OCS or higher. Elevations in serum cholesterol, total protein, potassium, and sorbitol dehydrogenase (SDH) occurred in rats fed the 500 ppm diet. Histological changes occurred in the liver and thyroid of rats exposed to as low as 5.0 ppm OCS. The OCS residues accumulated in the fat and liver in a dose-dependent manner. These data suggest that OCS can produce biochemical and histological changes in rats after administration of a single oral dose and/or when fed in the diet.
本研究旨在调查八氯苯乙烯（OCS）的急性和亚急性毒性，OCS是在北美五大湖以及欧洲挪威沿海鱼类体内证实存在的一种环境污染物。在一项急性研究中，将10只雄性大鼠分为一组，通过灌胃给予单剂量的OCS，剂量分别为1300、1690、2190、2850或3710mg/kg，并在14天后处死。剂量为1690mg/kg及以上的八氯苯乙烯可导致肝脏重量增加、肝微粒体苯胺羟化酶和氨基比林脱甲基酶活性增强，以及血清胆固醇和尿酸水平升高。在接受治疗的动物甲状腺中仅观察到轻微的组织学变化。在一项亚急性研究中，将10只雄性和雌性大鼠分为一组，喂食含0.5、5.0、50或500ppm OCS的饲料，持续28天。生长速率和食物消耗量不受治疗影响。在喂食50ppm及以上OCS的动物中观察到肝脏肥大和肝微粒体酶诱导现象。喂食500ppm饲料的大鼠血清胆固醇、总蛋白、钾和山梨醇脱氢酶（SDH）升高。暴露于低至5.0ppm OCS的大鼠肝脏和甲状腺出现组织学变化。OCS残留物以剂量依赖的方式在脂肪和肝脏中蓄积。这些数据表明，OCS在单次口服给药和/或喂食后可在大鼠体内产生生化和组织学变化。
