De Wals P, Hertoghe L, Reginster G, Borlee I, Bouckaert A, Dachy A, Lechat M F
J Infect. 1984 May;8(3):264-73. doi: 10.1016/s0163-4453(84)94123-9.
A survey of children admitted with meningococcal disease to 53 paediatric units in Belgium between 1975 and 1979 was made in order to assess the case mortality rate (CMR) and to identify risk factors associated with death. A total of 309 cases (226 bacteriologically confirmed and 83 unconfirmed) was recorded. The overall CMR was 6.1 per cent. It was 4.4 for bacteriologically confirmed cases and 10.8 for unconfirmed cases. The CMR was higher for septicaemia without meningitis (22.2 per cent) than for meningitis with or without signs of septicaemia (3.4 per cent). The risk of death was not related to the sex or nationality of the patients. Age was a major determinant of the CMR, independently of the clinical picture. The highest risk of death was in children under one year of age. Poor socio-economic conditions were a significant risk factor. Failure to recognise the severity of the disease by some poorly educated mothers, and the admission of the patient to a hospital lacking adequate facilities for managing severely affected children, were the two significant causes of delay of adequate treatment.
为评估病死率（CMR）并确定与死亡相关的危险因素，对1975年至1979年间比利时53个儿科病房收治的患脑膜炎球菌病的儿童进行了一项调查。共记录了309例病例（226例经细菌学确诊，83例未确诊）。总体病死率为6.1%。细菌学确诊病例的病死率为4.4%，未确诊病例的病死率为10.8%。无脑膜炎的败血症的病死率（22.2%）高于有或无败血症体征的脑膜炎的病死率（3.4%）。死亡风险与患者的性别或国籍无关。年龄是病死率的主要决定因素，与临床表现无关。一岁以下儿童的死亡风险最高。社会经济条件差是一个重要的危险因素。一些受教育程度低的母亲未认识到疾病的严重性，以及患者被收治到缺乏管理重症儿童适当设施的医院，是充分治疗延误的两个重要原因。
