Curcio C A, Kemper T
J Neuropathol Exp Neurol. 1984 Jul;43(4):359-68. doi: 10.1097/00005072-198407000-00001.
Within the reticulate core of the brain the nucleus raphe dorsalis (NRD) is a major site of predilection for the neurofibrillary tangle (NFT) in dementia of the Alzheimer type (DAT) and, according to some studies, its primary brain stem site. In a quantitative study we have shown in six aged control brains an average of 5.2 NFT per histological section or 25.8 per mm3 and in seven age-matched brains with DAT a highly significant six-fold increase, respectively 35.3 NFT per histological section or 188.5 per mm3. There was no significant difference between the two groups in overall neuronal cell packing density. There was, however, a significant decrease in a subpopulation of neurons in DAT, a large polygonal neuron. Despite the prominence of the NRD as a target for NFT, the actual proportion of affected NRD cells was small, 0.35% in controls and 2.25% in DAT.
在脑桥的网状核心内，背侧中缝核（NRD）是阿尔茨海默型痴呆（DAT）中神经原纤维缠结（NFT）的主要聚集部位，根据一些研究，它也是NFT在脑干的主要部位。在一项定量研究中，我们在6个老年对照脑中发现，每个组织学切片平均有5.2个NFT，或每立方毫米有25.8个NFT；而在7个年龄匹配的DAT脑中，NFT数量显著增加了6倍，分别为每个组织学切片35.3个NFT或每立方毫米188.5个NFT。两组在总体神经元细胞堆积密度上没有显著差异。然而，在DAT中，一种大的多角形神经元亚群的数量显著减少。尽管NRD是NFT的主要靶点，但受影响的NRD细胞的实际比例很小，对照组为0.35%，DAT组为2.25%。
