Yamamoto T, Hirano A
Acta Neuropathol. 1985;67(3-4):296-9. doi: 10.1007/BF00687815.
Recently, morphometric analysis has shown that the nucleus raphe dorsalis, which is presumed to project diffuse serotonergic fibers to the telencephalon, is affected in Alzheimer's disease. A similar study was conducted in this report in two patients with parkinsonism-dementia complex of Guam and a Guamanian control. It demonstrated a significant reduction in the number of large neurons, and the presence of abundant Alzheimer's neurofibrillary tangles in this nucleus.
最近，形态计量学分析表明，背侧中缝核被认为向端脑投射弥散性5-羟色胺能纤维，在阿尔茨海默病中会受到影响。本报告对两名关岛帕金森病痴呆综合征患者和一名关岛对照者进行了类似研究。结果显示该核中大神经元数量显著减少，且存在大量阿尔茨海默病神经原纤维缠结。
