Hofman M A
J Neurol. 1984;231(2):87-93. doi: 10.1007/BF00313723.
Brain weight and head circumference in micrencephalic patients were analysed as a function of age, height and sex in relation to normal human standards. A quantitative definition of micrencephaly is proposed, which is based on these analyses. Evidence is presented, furthermore, that micrencephalics have a significantly lower brain weight in adolescence than in early childhood, and that this cerebral dystrophy continues throughout adulthood, leading to death in more than 85% of the males and 78% of the females before they reach the age of 30 years. Since this decline in brain weight after approximately 3-5 years of age is not accompanied by a similar reduction in head circumference, the brains of elderly micrencephalic patients no longer occupy the entire cranial cavity. It is evident, therefore, that head circumference in the case of micrencephaly is an unsuitable parameter for estimating brain size.
对小头畸形患者的脑重量和头围进行了分析，将其作为年龄、身高和性别的函数，并与正常人类标准进行比较。基于这些分析，提出了小头畸形的定量定义。此外，有证据表明，小头畸形患者在青春期的脑重量明显低于幼儿期，并且这种脑萎缩在整个成年期持续存在，导致超过85%的男性和78%的女性在30岁之前死亡。由于大约3至5岁后脑重量的下降并未伴随着头围的类似减少，老年小头畸形患者的大脑不再占据整个颅腔。因此，很明显，在小头畸形的情况下，头围是估计脑大小的不合适参数。
