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18例催乳素腺瘤的纵向研究。治疗结果(作者译)

[Longitudinal study of 18 cases of prolactin adenoma. Therapeutic results (author's transl)].

作者信息

de Gennes J L, Turpin G, Heshmati H M, Cesselin E, Lagoguey M

出版信息

Nouv Presse Med. 1978 May 20;7(20):1713-7.

PMID:673715
Abstract

Complete endocrinological studies were made before and after surgery in 18 cases of prolactin adenoma (2 giant adenomas and 16 macro-adenomas). Certain points are stressed: the frequency of the haemorrhagic nature of the adenoma in 4 cases, including 1 case of spontaneous necrosis; the great variability in dynamic responses to the TRH stimulation test or inhibition by I-Dopa; the persistence in 14 cases out of 16 of postoperative hyperproclactinaemia, requiring the prescription of 5 to 10 mg/day of bromocriptine, rarely more; the disappearance of total impotence in two male cases as a result of the latter drug, whilst testerone and dihydrotestosterone levels were normal before the beginning of medical treatment.

摘要

对18例催乳素腺瘤(2例巨大腺瘤和16例大腺瘤)患者在手术前后进行了全面的内分泌学研究。着重强调了以下几点:4例腺瘤具有出血性质,其中1例为自发性坏死;对促甲状腺激素释放激素(TRH)刺激试验或左旋多巴抑制的动态反应差异很大;16例中有14例术后高催乳素血症持续存在,需要服用5至10毫克/天的溴隐亭,很少超过此剂量;两名男性患者因服用该药完全阳痿消失,而在开始药物治疗前睾酮和双氢睾酮水平正常。

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