Fukuda K, Nishi Y, Usui T
J Pediatr Gastroenterol Nutr. 1984 Jun;3(3):432-9. doi: 10.1097/00005176-198406000-00022.
Concentrations of free amino acids were measured concurrently in plasma, erythrocytes, granulocytes, and lymphocytes in umbilical cord blood, neonates, children, and adults. In each age group, the patterns of free amino acids were fairly similar in plasma and erythrocytes except for aspartic acid which was more abundant in erythrocytes. Of the amino acids in granulocytes, 71-77% was taurine; in lymphocytes taurine, aspartic acid, and glutamic acid comprised 35-44%, 18-24%, and 20-28%, respectively, of the total in all age groups. Leukocytes may contribute to the interorgan transport of amino acids to about 10% of the erythrocytes' contribution. Postnatally, the levels of glutamic acid and tyrosine in plasma; threonine plus glutamine, serine plus asparagine, and tyrosine in erythrocytes; histidine in granulocytes; and glutamic acid in lymphocytes were significantly increased (p less than 0.001); while the levels of phenylalanine and lysine in plasma; taurine in erythrocytes; valine and phenylalanine in granulocytes; and threonine plus glutamine, tyrosine, and phenylalanine in lymphocytes were significantly decreased (p less than 0.001). After the neonatal period concentrations of taurine and aspartic acid in erythrocytes, taurine and valine in granulocytes, and tyrosine and phenylalanine in lymphocytes increased gradually with age; while concentrations aspartic acid in plasma, histidine in granulocytes, and glycine in lymphocytes decreased gradually with age. The levels of glycine and valine in plasma, alanine and valine in erythrocytes, serine plus asparagine, glycine, alanine, and tyrosine in granulocytes, and aspartic acid, serine plus asparagine, and alanine in lymphocytes remained constant in all age groups.(ABSTRACT TRUNCATED AT 250 WORDS)
同时测定了脐带血、新生儿、儿童和成人血浆、红细胞、粒细胞和淋巴细胞中游离氨基酸的浓度。在每个年龄组中，血浆和红细胞中游离氨基酸的模式相当相似，除了红细胞中天冬氨酸含量更高。粒细胞中的氨基酸，71 - 77%是牛磺酸；淋巴细胞中，所有年龄组牛磺酸、天冬氨酸和谷氨酸分别占总量的35 - 44%、18 - 24%和20 - 28%。白细胞对氨基酸的器官间转运贡献约为红细胞的10%。出生后，血浆中谷氨酸和酪氨酸水平；红细胞中苏氨酸加谷氨酰胺、丝氨酸加天冬酰胺和酪氨酸水平；粒细胞中组氨酸水平；淋巴细胞中谷氨酸水平显著升高（p小于0.001）；而血浆中苯丙氨酸和赖氨酸水平；红细胞中牛磺酸水平；粒细胞中缬氨酸和苯丙氨酸水平；淋巴细胞中苏氨酸加谷氨酰胺、酪氨酸和苯丙氨酸水平显著降低（p小于0.001）。新生儿期后，红细胞中牛磺酸和天冬氨酸、粒细胞中牛磺酸和缬氨酸、淋巴细胞中酪氨酸和苯丙氨酸的浓度随年龄逐渐增加；而血浆中天冬氨酸、粒细胞中组氨酸、淋巴细胞中甘氨酸的浓度随年龄逐渐降低。所有年龄组中，血浆中甘氨酸和缬氨酸水平、红细胞中丙氨酸和缬氨酸水平、粒细胞中丝氨酸加天冬酰胺、甘氨酸、丙氨酸和酪氨酸水平、淋巴细胞中天冬氨酸、丝氨酸加天冬酰胺和丙氨酸水平保持恒定。（摘要截选至250字）
