Chapman K R, Rebuck A S
J Physiol. 1984 Apr;349:73-82. doi: 10.1113/jphysiol.1984.sp015143.
Respiratory frequency and separate rib-cage and abdomen-diaphragm compartmental tidal volume (VT) responses to progressive isocapnic hypoxia to a level of 75% O2 saturation (PO2 approximately 40 torr) were measured in eight healthy subjects in both seated and supine postures. Hypoxia was induced by a rebreathing technique and compartmental contributions to VT were measured by inductive plethysmography. The ventilatory, frequency and spirometric VT responses to hypoxia did not differ significantly between sitting and supine trials. The range of VT responsiveness to hypoxia among sitting individuals (0.71 +/- S.D. = 0.56% VC X % fall in Sa,O2(-1), where VC is vital capacity and Sa,O2 is arterial O2 saturation) was determined by both rib-cage (0.507 +/- S.D. = 0.378% VC X % fall in Sa,O2(-1) ) and abdomen-diaphragm (0.194 +/- S.D. = 0.178% VC X % fall fall in Sa,O2(-1) ) compartments. Among supine individuals the range of VT responsiveness to hypoxia (0.49 +/- S.D. = 0.45% VC X % fall in Sa,O2(-1) was determined equally by both rib-cage (0.27 +/- S.D. = 0.31% VC X % fall in SA,O2(-1) ) and abdomen-diaphragm (0.23 +/- S.D. = 0.29% VC X % fall in Sa,O2(-1) ) compartments. Thus, the VT response to progressive isocapnic hypoxia in conscious man is determined by both rib-cage and abdomen-diaphragm compartments regardless of posture.
在8名健康受试者处于坐姿和仰卧位时，测量了呼吸频率以及胸廓和腹部 - 膈肌分区的潮气量（VT）对渐进性等碳酸血症性低氧至氧饱和度75%（PO2约40托）水平的反应。通过重复呼吸技术诱导低氧，并通过感应式体积描记法测量VT的分区贡献。在坐姿和仰卧位试验中，对低氧的通气、频率和肺活量计VT反应无显著差异。坐姿个体中对低氧的VT反应范围（0.71±标准差 = 0.56%肺活量×动脉血氧饱和度（SaO2）下降百分比（-1），其中肺活量（VC）是肺活量，SaO2是动脉血氧饱和度）由胸廓（0.507±标准差 = 0.378%肺活量×SaO2下降百分比（-1））和腹部 - 膈肌（0.194±标准差 = 0.178%肺活量×SaO2下降百分比（-1））分区共同决定。在仰卧位个体中，对低氧的VT反应范围（0.49±标准差 = 0.45%肺活量×SaO2下降百分比（-1））同样由胸廓（0.27±标准差 = 0.31%肺活量×SaO2下降百分比（-1））和腹部 - 膈肌（0.23±标准差 = 0.29%肺活量×SaO2下降百分比（-1））分区决定。因此，无论姿势如何，清醒男性对渐进性等碳酸血症性低氧的VT反应由胸廓和腹部 - 膈肌分区共同决定。
