Gothe B, Goldman M D, Cherniack N S, Mantey P
Am Rev Respir Dis. 1982 Jul;126(1):97-102. doi: 10.1164/arrd.1982.126.1.97.
We examined the effects of progressive hypoxia on breathing during wakefulness and quiet (NREM) sleep in 17 healthy young adults (11 males and 6 females). Ventilation was determined from quantitative measurements of abdominal and rib cage excursions using magnetometers or inductive plethysmography. Hypoxia was induced by blending N2 into the inspiratory line of a loose-fitting mask while O2 saturation was monitored with an ear oximeter. No attempt was made to maintain isocapnia. Ventilatory responses to hypoxia were depressed in 2 male subjects by sleep, but were unchanged or increased in the others. Thus on the average, sleep produced no change in ventilatory responses to hypoxia. There was no consistent difference in the frequencies or tidal volumes attained at a given level of ventilation during hypoxia awake and asleep. During sleep there was relatively more rib cage than abdominal movement. Relief of hypoxia was followed by periodic breathing during sleep in 12 subjects but in only 2 subjects when awake. In two thirds of the trials, hypoxia failed to produce arousal even though arterial O2 saturation was allowed to fall below 75%. The results suggest that (1) sleep potentiates apnea producing effects of O2 changes but has inconsistent effects on ventilatory responses to hypoxia, and (2) hypocapnic hypoxia is not an invariably potent stimulus for arousal.
我们研究了进行性低氧对17名健康年轻成年人（11名男性和6名女性）清醒和安静（非快速眼动）睡眠期间呼吸的影响。使用磁力计或感应式体积描记法通过对腹部和胸廓运动的定量测量来确定通气情况。通过将氮气混入宽松面罩的吸气管路来诱导低氧，同时用耳部血氧计监测血氧饱和度。未尝试维持等碳酸血症。睡眠使2名男性受试者对低氧的通气反应降低，但其他受试者的反应未改变或增加。因此，平均而言，睡眠对低氧通气反应没有影响。在低氧状态下清醒和睡眠时，在给定通气水平下达到的频率或潮气量没有一致的差异。睡眠期间胸廓运动比腹部运动相对更多。低氧缓解后，12名受试者在睡眠期间出现周期性呼吸，但清醒时只有2名受试者出现。在三分之二的试验中，即使动脉血氧饱和度降至75%以下，低氧也未能引起觉醒。结果表明：（1）睡眠增强了氧气变化产生呼吸暂停的作用，但对低氧通气反应的影响不一致；（2）低碳酸血症性低氧并非总是引起觉醒的有效刺激。
