咪康唑对血液系统恶性肿瘤患者真菌感染的治疗作用

[Therapeutic effect of miconazole on fungal infection in patients with hematological malignancies].

作者信息

Nagai K, Yabe H, Yoshida T, Nakayama S

出版信息

Jpn J Antibiot. 1984 Mar;37(3):303-8.

Abstract

The effectiveness of miconazole was evaluated in 9 documented fungal infections, 4 of which were candidal sepsis. All patients were receiving therapy for hematological malignancies. Miconazole revealed the excellent effect in 3 patients with candidal esophagitis and 1 patient with candidal sepsis and esophagitis. Twelve patients who received miconazole for presumed or documented fungal infection were evaluated for toxicity. No particular side effects, except for only 1 case of mild hepatic dysfunction, were observed. Miconazole is apparently an effective antifungal agents for treatment of systemic fungal infection in patients with hematological malignancies.

摘要

对9例有记录的真菌感染患者评估了咪康唑的疗效，其中4例为念珠菌败血症。所有患者均因血液系统恶性肿瘤接受治疗。咪康唑在3例念珠菌食管炎患者和1例念珠菌败血症合并食管炎患者中显示出极佳疗效。对12例因疑似或确诊真菌感染而接受咪康唑治疗的患者进行了毒性评估。除仅1例出现轻度肝功能障碍外，未观察到其他特殊副作用。咪康唑显然是治疗血液系统恶性肿瘤患者系统性真菌感染的有效抗真菌药物。