Alteration of GABA levels in ovary and fallopian tube of the pregnant rat.

The concentration and the total quantity of gamma-aminobutyric acid (GABA) were determined in ovary and Fallopian tube of the rat on day 3, 7, 14 and 21 of pregnancy and the values were compared with a diestrous control group. In ovary, both GABA concentration and total GABA content gradually elevated up to day 14 of gestation but, thereafter, the diminution of the two parameters was observed. The GABA concentrations in Fallopian tube were found to be strongly reduced during pregnancy, and the total amount of the amino acid in this organ also decreased markedly. The significant alterations of GABA levels in both organs suggest a possible correlation between the functional status and GABA content of ovary and Fallopian tube of the pregnant rat.