PHA刺激人淋巴细胞过程中不同RNA聚合酶I和II池的活性之间的关系。
The relationship between the activities of different pools of RNA polymerases I and II during PHA-stimulation of human lymphocytes.
作者信息
Tillyer C R, Butterworth P H
出版信息
Nucleic Acids Res. 1978 Jun;5(6):2099-111. doi: 10.1093/nar/5.6.2099.
Abstract
Following PHA-stimulation of lymphocytes in culture, it is known that nuclear RNA synthesis and the amount of extractable RNA polymerase activity rise in these cells. The relationship between these two phenomena has been examined. Using an in vitro assay system which discriminates between polymerase activity which is "engaged" in nuclear RNA synthesis and a pool of "free" enzyme, the data suggest that the factors regulating the interaction between these two pools of enzyme activity are different for forms I and II RNA polymerases.
摘要
已知在培养中用PHA刺激淋巴细胞后，这些细胞中的核RNA合成及可提取的RNA聚合酶活性会升高。已对这两种现象之间的关系进行了研究。使用一种体外测定系统来区分“参与”核RNA合成的聚合酶活性和“游离”酶库，数据表明，调节这两种酶活性库之间相互作用的因素对于I型和II型RNA聚合酶是不同的。
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