关于糖尿病酮症酸中毒时血清淀粉酶升高的原因

On the cause of raised serum-amylase in diabetic ketoacidosis.

作者信息

Warshaw A L, Feller E R, Lee K H

出版信息

Lancet. 1977 Apr 30;1(8018):929-31. doi: 10.1016/s0140-6736(77)92225-5.

Abstract

7 of 13 patients with diabetic ketoacidosis had raised serum-amylase concentrations. Isoenzymes analysis by polyacrylamide-gel electrophoresis showed that salivary-type amylases and not pancreatic-type amylases were responsible for the rise in 6 or the 7 cases. This demonstrates that the pancreas is usually not the origin of the increase in serum-amylase. Since salivary-type amylases are widely distributed in glandular epithelium, it is suggested that hyperamylasaemia in diabetic ketoacidosis is most often caused by systemic derangement of carbohydrate metabolism.

摘要

13例糖尿病酮症酸中毒患者中有7例血清淀粉酶浓度升高。通过聚丙烯酰胺凝胶电泳进行的同工酶分析表明，6例或7例患者血清淀粉酶升高是由唾液型淀粉酶而非胰腺型淀粉酶引起的。这表明胰腺通常不是血清淀粉酶升高的来源。由于唾液型淀粉酶广泛分布于腺上皮，提示糖尿病酮症酸中毒时高淀粉酶血症最常见的原因是碳水化合物代谢的全身性紊乱。