糖尿病酮症酸中毒时高淀粉酶血症和腹痛的意义
Significance of hyperamylasaemia and abdominal pain in diabetic ketoacidosis.
作者信息
Knight A H, Williams D N, Ellis G, Goldberg D M
出版信息
Br Med J. 1973 Jul 21;3(5872):128-31. doi: 10.1136/bmj.3.5872.128.
Abstract
An analysis of 35 consecutive episodes of diabetic ketoacidosis confirmed the frequent high levels of serum amylase in this condition. Serum amylase was raised during 21 episodes (60%), and in six instances (17%) the peak level exceeded 1,000 Somogyi units per 100 ml. Hyperamylasaemia was more often found when the initial blood sugar exceeded 500 mg/100 ml, or when the onset of the episode had been relatively acute (less than 48 hours). There was no conclusive evidence in any patient to support a diagnosis of acute pancreatitis and other explanations for the hyperamylasaemia are discussed. Even grossly raised amylase levels were not associated with increased mortality or morbidity.
摘要
对35例连续性糖尿病酮症酸中毒病例的分析证实，在此病症中血清淀粉酶水平常常偏高。21例（60%）病例的血清淀粉酶升高，6例（17%）的峰值水平超过每100毫升1000索莫吉单位。当初始血糖超过500毫克/100毫升，或者病症发作相对急性（少于48小时）时，更常出现高淀粉酶血症。没有任何患者有确凿证据支持急性胰腺炎的诊断，文中讨论了高淀粉酶血症的其他解释。即便淀粉酶水平大幅升高也与死亡率或发病率增加无关。
相似文献
1
Significance of hyperamylasaemia and abdominal pain in diabetic ketoacidosis.糖尿病酮症酸中毒时高淀粉酶血症和腹痛的意义
Br Med J. 1973 Jul 21;3(5872):128-31. doi: 10.1136/bmj.3.5872.128.
2
[Blood amylase and lipase in diabetic ketoacidosis].
Presse Med. 1987 May 16;16(18):895-8.
3
Nonspecific hyperamylasemia and hyperlipasemia in diabetic ketoacidosis: incidence and correlation with biochemical abnormalities.糖尿病酮症酸中毒中的非特异性高淀粉酶血症和高脂肪酶血症：发病率及其与生化异常的相关性
Am J Gastroenterol. 2000 Nov;95(11):3123-8. doi: 10.1111/j.1572-0241.2000.03279.x.
4
On the cause of raised serum-amylase in diabetic ketoacidosis.关于糖尿病酮症酸中毒时血清淀粉酶升高的原因
Lancet. 1977 Apr 30;1(8018):929-31. doi: 10.1016/s0140-6736(77)92225-5.
5
Acute Pancreatitis Complicated with Diabetic Ketoacidosis in a Young Adult without Hypertriglyceridemia: A Case Report.一名无高甘油三酯血症的年轻成人急性胰腺炎合并糖尿病酮症酸中毒：病例报告
Korean J Gastroenterol. 2016 Nov 25;68(5):274-278. doi: 10.4166/kjg.2016.68.5.274.
6
Serum amylase during recovery from diabetic ketoacidosis.
Diabete Metab. 1984 Jan;10(1):25-30.
7
Serum amylase and lipase in the evaluation of acute abdominal pain.血清淀粉酶和脂肪酶在急性腹痛评估中的应用
Am Surg. 1996 Dec;62(12):1028-33.
8
Changes in serum amylase, lipase and leukocyte elastase during diabetic ketoacidosis and poorly controlled diabetes.糖尿病酮症酸中毒和控制不佳的糖尿病期间血清淀粉酶、脂肪酶和白细胞弹性蛋白酶的变化。
Acta Diabetol. 1999 Jun;36(1-2):39-44. doi: 10.1007/s005920050143.
9
Serum amylase and lipase in diabetic ketoacidosis.糖尿病酮症酸中毒中的血清淀粉酶和脂肪酶
Diabetes Care. 2003 Nov;26(11):3193-4. doi: 10.2337/diacare.26.11.3193.
10
Association of diabetic ketoacidosis and acute pancreatitis: observations in 100 consecutive episodes of DKA.糖尿病酮症酸中毒与急性胰腺炎的关联：对100例连续糖尿病酮症酸中毒发作的观察
Am J Gastroenterol. 2000 Oct;95(10):2795-800. doi: 10.1111/j.1572-0241.2000.03188.x.
引用本文的文献
1
Diabetic Ketoacidosis With Acute Pancreatitis in Patients With Type 2 Diabetes in the Emergency Department: A Retrospective Study.急诊科2型糖尿病患者合并急性胰腺炎的糖尿病酮症酸中毒：一项回顾性研究
Front Med (Lausanne). 2022 Mar 17;9:813083. doi: 10.3389/fmed.2022.813083. eCollection 2022.
2
Gastrointestinal Manifestations of Systemic Diseases in Critically Ill.危重症患者全身性疾病的胃肠道表现
Indian J Crit Care Med. 2020 Sep;24(Suppl 4):S190-S192. doi: 10.5005/jp-journals-10071-23610.
3
Low serum amylase and obesity, diabetes and metabolic syndrome: A novel interpretation.低血清淀粉酶与肥胖、糖尿病和代谢综合征：一种新的解读。
World J Diabetes. 2016 Mar 25;7(6):112-21. doi: 10.4239/wjd.v7.i6.112.
4
Acute pancreatitis with diabetic ketoacidosis associated with hypermyoglobinemia, acute renal failure, and DIC.
J Gastroenterol. 1996 Aug;31(4):623-6. doi: 10.1007/BF02355070.
5
Hyperamylasaemia in glycogen storage disease type 1.
Eur J Pediatr. 1993 Jul;152(7):623. doi: 10.1007/BF01954099.
6
Gastrointestinal manifestations of diabetic ketoacidosis.糖尿病酮症酸中毒的胃肠道表现。
Yale J Biol Med. 1983 May-Jun;56(3):175-8.
7
Lactic acidosis and hyperamylasaemia associated with phenformin therapy.与苯乙双胍治疗相关的乳酸性酸中毒和高淀粉酶血症。
Postgrad Med J. 1974 Dec;50(590):765-66. doi: 10.1136/pgmj.50.590.765.
8
Onset of diabetic ketoacidosis with symptoms of acute abdomen during oral mestranol treatment.
Acta Diabetol Lat. 1974 Mar-Apr;11(2):136-9. doi: 10.1007/BF02581312.
9
Proceedings: Serum amylase and related enzymes in diabetic ketoacidosis.论文集：糖尿病酮症酸中毒中的血清淀粉酶及相关酶
J Clin Pathol. 1973 Dec;26(12):985. doi: 10.1136/jcp.26.12.985-b.
10
Letter: Acute pancreatitis and diabetic ketoacidosis in hypothermia.信件：低温状态下的急性胰腺炎与糖尿病酮症酸中毒
Br Med J. 1974 Jan 26;1(5899):159. doi: 10.1136/bmj.1.5899.159-a.
本文引用的文献
1
Diabetic acidosis with acute pancreatitis.糖尿病酸中毒伴急性胰腺炎。
Br J Surg. 1961 Jul;49:90-1. doi: 10.1002/bjs.18004921320.
2
The plasma amylase. Source, regulation and diagnostic significance.血浆淀粉酶：来源、调节及诊断意义
Am J Med. 1959 Dec;27:924-35. doi: 10.1016/0002-9343(59)90176-7.
3
The evaluation of serum amylase levels in nonpancreatic disease.
Arch Surg. 1960 Mar;80:482-5. doi: 10.1001/archsurg.1960.01290200126022.
4
Acute pancreatitis; analysis of 100 patients.急性胰腺炎；100例患者分析
Br Med J. 1959 Jan 3;1(5113):6-14. doi: 10.1136/bmj.1.5113.6.
5
Amylase distribution in extrapancreatic, extrasalivary tissues.
Arch Biochem Biophys. 1958 Jun;75(2):403-11. doi: 10.1016/0003-9861(58)90439-9.
6
The diabetic coma of acute pancreatitis.急性胰腺炎所致的糖尿病昏迷
Ann Intern Med. 1958 Feb;48(2):310-9. doi: 10.7326/0003-4819-48-2-310.
7
Acute pancreatitis complicating diabetes mellitus.急性胰腺炎合并糖尿病
AMA Arch Intern Med. 1956 Feb;97(2):201-7. doi: 10.1001/archinte.1956.00250200077007.
8
Acute methyl alcohol poisoning: a review based on experiences in an outbreak of 323 cases.急性甲醇中毒：基于323例暴发疫情经验的综述
Medicine (Baltimore). 1953 Dec;32(4):431-63. doi: 10.1097/00005792-195312000-00002.
9
Macroamylasemia: rapid detection method.巨淀粉酶血症：快速检测方法
Clin Chem. 1971 May;17(5):423-6.
10
A comparative study of the isoenzymes of mammalian alpha-amylase.哺乳动物α-淀粉酶同工酶的比较研究。
Enzyme. 1971;12(2):180-6. doi: 10.1159/000459530.
Zotero 插件