Weiner C P, Kwaan H, Hauck W W, Duboe F J, Paul M, Wallemark C B
Obstet Gynecol. 1984 Jul;64(1):46-8.
Both clinical and laboratory findings suggest that pregnancy constitutes a hypercoagulable condition; yet none of the observed laboratory changes are specific for thrombosis. An essential step involves thrombin-mediated fibrin generation. In the process, fibrinopeptide A (FPA) is cleaved from fibrinogen. Using a radioimmune assay, FPA was determined prospectively in a longitudinal and cross-sectional fashion. Fibrinopeptide A increased significantly over control by the end of the first trimester, from 1.3 ng/ml to 2.8 ng/ml. It continued to increase until 30 to 32 weeks' gestation and then plateaued at 4.3 to 4.7 ng/ml. In the immediate postpartum period, FPA remains elevated. In conclusion, thrombin generation as reflected in FPA production is increased throughout pregnancy, thus confirming a hypercoagulable milieu.
临床和实验室检查结果均表明，妊娠构成一种高凝状态；然而，所观察到的实验室变化均非血栓形成的特异性表现。一个关键步骤涉及凝血酶介导的纤维蛋白生成。在此过程中，纤维蛋白原中的纤维蛋白肽A（FPA）被裂解。采用放射免疫分析法，对FPA进行了纵向和横向的前瞻性测定。在孕早期结束时，FPA较对照组显著升高，从1.3 ng/ml升至2.8 ng/ml。它持续升高直至妊娠30至32周，然后稳定在4.3至4.7 ng/ml。在产后即刻，FPA仍保持升高。总之，整个孕期FPA生成所反映的凝血酶生成增加，从而证实了高凝环境。
