Kulnig W, Binder S, Riss B, Skorpik C
Ophthalmologica. 1984;188(4):248-58. doi: 10.1159/000309371.
5-Fluouracil, administered at concentrations of 1 and 5 mg to inhibit experimental intraocular proliferation produced by intravitreously implanted fibroblasts in rabbits, produced tissue alterations revealed by TEM. The degranulation and migration of pigment epithelial cells, the incipient degradation of axons and myelin sheets, the migration of glial cells and the prominent edema of the inner layers indicated a non-negligible damage to the retina, suggesting to abstain from its use in human eyes and to search for less neurotoxic drugs, possessing the same inhibitory effect on intraocular proliferation.
5-氟尿嘧啶以1毫克和5毫克的浓度给药，以抑制兔眼玻璃体内植入成纤维细胞产生的实验性眼内增殖，透射电子显微镜显示其产生了组织改变。色素上皮细胞的脱颗粒和迁移、轴突和髓鞘的早期降解、神经胶质细胞的迁移以及内层的明显水肿表明对视网膜造成了不可忽视的损害，这表明应避免在人眼中使用该药物，并寻找对眼内增殖具有相同抑制作用但神经毒性较小的药物。
