Binder S, Bonnet M, Velikay M, Gerard J P, Stolba U, Wedrich A, Hohenberg H
I. University Eye Hospital Vienna, Austria.
Graefes Arch Clin Exp Ophthalmol. 1994 Apr;232(4):211-4. doi: 10.1007/BF00184007.
In a prospective study of the effect of postoperative radiation therapy for the prevention of reproliferation of membranes and recurrent proliferative vitreoretinopathy (PVR) two similar groups of patients with retinal detachment and PVR grade D1 to D3 in one eye were compared. Half the eyes (30) received a total dose of 3000 cGy after surgery; the other half remained untreated. After a follow-up of 6 months and 14 months or more (maximum 36 months) the anatomical and functional results of each group were compared. After 6 months in the unirradiated group 57% (17/30) remained attached and 43% (13/30) had detached again. In the irradiated group 63% (19/30) were attached and 37% (11/30) had detached. However, there was no statistically significant difference between the two groups (P = 0.479, Fisher's Exact Test). After 14 months the number of cured and uncured eyes remained the same in the unirradiated group, while in four of the eyes in the irradiated group a later onset of reproliferation and detachment occurred (after 7, 8, 12 and 14 months, respectively). A final cure rate of 57% (17/30) was achieved in the unirradiated group and a 50% (15/30) cure rate in the irradiated group. Thus the failure rate was 43% (13/30) in the unirradiated group and 50% (15/30) in the irradiated group (P = 0.473, Fisher's Exact Test). No side effects from the radiation were observed in any case and no radiation retinopathy occurred during an observation period of up to 3 years.(ABSTRACT TRUNCATED AT 250 WORDS)
在一项关于术后放射治疗预防膜再增殖和复发性增殖性玻璃体视网膜病变（PVR）效果的前瞻性研究中，对两组单眼视网膜脱离且PVR分级为D1至D3的相似患者进行了比较。其中一半眼睛（30只）在手术后接受了3000 cGy的总剂量照射；另一半未接受治疗。在随访6个月以及14个月或更长时间（最长36个月）后，比较了每组的解剖学和功能结果。6个月后，未照射组中有57%（17/30）的眼睛仍保持附着状态，43%（13/30）的眼睛再次脱离。照射组中，63%（19/30）的眼睛保持附着，37%（11/30）的眼睛脱离。然而，两组之间在统计学上没有显著差异（P = 0.479，Fisher精确检验）。14个月后，未照射组中治愈和未治愈的眼睛数量保持不变，而照射组中有4只眼睛出现了较晚的再增殖和脱离（分别在7、8、12和14个月后）。未照射组的最终治愈率为57%（17/30），照射组为50%（15/30）。因此，未照射组的失败率为43%（13/30），照射组为50%（15/30）（P = 0.473，Fisher精确检验）。在任何情况下均未观察到放疗的副作用，并且在长达3年的观察期内未发生放射性视网膜病变。（摘要截短至250字）
