Dolan T T, Teale A J, Stagg D A, Kemp S J, Cowan K M, Young A S, Groocock C M, Leitch B L, Spooner R L, Brown C G
Parasite Immunol. 1984 May;6(3):243-50. doi: 10.1111/j.1365-3024.1984.tb00797.x.
Histocompatibility may be a barrier to the infection of cattle when Theileria parva parva-infected tissues or in vitro cultured macroschizont-infected lymphoblastoid cell lines are used for immunization. By inoculating 10(3) and 10(5) infected cells into autologous recipients infection was achieved and immunity engendered. Cell lines inoculated into BoLA matched recipients did not produce patent infections but some recipients developed antibodies to the parasite and 3/5 were immune to challenge. No evidence of infection or immunity was found in BoLA half matched or mismatched cattle. This result suggests that there is an histocompatibility barrier to infection using T. p. parva-infected lymphoblastoid cells.
当使用感染了小泰勒虫的组织或体外培养的大裂殖体感染的淋巴母细胞系进行免疫时，组织相容性可能是牛感染的一个障碍。通过将10³和10⁵个感染细胞接种到自体受体中，实现了感染并产生了免疫力。接种到与牛白细胞抗原（BoLA）匹配的受体中的细胞系未产生显性感染，但一些受体产生了针对该寄生虫的抗体，并且5只中有3只对攻击具有免疫力。在BoLA半匹配或不匹配的牛中未发现感染或免疫的证据。这一结果表明，使用感染小泰勒虫的淋巴母细胞进行感染存在组织相容性障碍。
