Sukhdeo M V, Mettrick D F
Parasitology. 1984 Jun;88 ( Pt 3):421-30. doi: 10.1017/s003118200005469x.
The effects of the direction of gut flow, of injections of glucose and saline into different regions of the small intestine and of surgical re-routing or ligature of gastric, biliary and pancreatic secretions into the small intestine have been correlated with changes in the migratory response of the rat tapeworm Hymenolepis diminuta. Reversing the normal anterior to distal flow of luminal contents in the small intestine did not affect worm migration following feeding. Injections of a glucose-saline solution into the duodenum did not initiate a migratory response; similar injections into the mid- and posterior regions of the small intestine resulted in migrational responses similar to those following intragastric glucose feeding. Re-routing gastric secretions to the distal duodenum inhibited anterior migration of the worms beyond the new point of entry of gastric juices. Results following re-routing and ligation of the biliary and pancreatic secretions suggest that there is a potent cue to anteriad migration in the pancreatic secretions. Biliary secretions also appear to contain an additional migratory cue to worm migration. In order of importance the factors stimulating/inhibiting worm migration are pancreatic greater than gastric greater than biliary greater than glucose. The results support the hypothesis that the factors affecting worm distribution in the small intestine are interactive and synergistic, involve other luminal factors, such as 5-hydroxytryptamine and the physico-chemical gradients, and are of a regional nature such that the migratory response of a particular worm is directly related to its position in the small intestine when the cues to relocation are received.
已将肠道流动方向、向小肠不同区域注射葡萄糖和生理盐水以及将胃、胆汁和胰液分泌进行手术改道或结扎并注入小肠等操作的影响，与大鼠绦虫微小膜壳绦虫迁移反应的变化进行了关联研究。将小肠腔内内容物正常的从前向后流动方向逆转，并不会影响喂食后蠕虫的迁移。向十二指肠注射葡萄糖 - 生理盐水溶液不会引发迁移反应；向小肠中部和后部进行类似注射，则会产生与胃内注射葡萄糖后相似的迁移反应。将胃分泌液改道至十二指肠远端会抑制蠕虫向前迁移至胃液新进入点之外。对胆汁和胰液分泌进行改道和结扎后的结果表明，胰液分泌中存在促使蠕虫向前迁移的有效信号。胆汁分泌似乎也含有另外一种促使蠕虫迁移的信号。刺激/抑制蠕虫迁移的因素按重要性排序为：胰液大于胃液大于胆汁大于葡萄糖。这些结果支持了这样一种假说，即影响蠕虫在小肠内分布的因素是相互作用且协同的，涉及其他腔内因素，如5 - 羟色胺和物理化学梯度，并且具有区域性质，使得当接收到重新定位的信号时，特定蠕虫的迁移反应与其在小肠中的位置直接相关。
