Mettrick D F, Cho C H
Can J Physiol Pharmacol. 1981 Mar;59(3):281-6. doi: 10.1139/y81-044.
Changes in the distribution of the tapeworm Hymenolepis diminuta in the rat small intestine were studied for up to 3 h following intraperitoneal, intramuscular, subcutaneous, and oral administration of 5-HT. Changes in 5-HT levels in the arterial circulation, intestinal lumen, and in worm tissue were also monitored. In all cases following 5-HT administration there was an anteriad migration by H. diminuta. The extent of the migration was dose dependent, the higher the dose the more marked the migration response. Normal 5-HT levels in the parasitized gut are higher than those in uninfected animals. The pattern of increasing levels of 5-HT in worm tissue directly followed the increases in the intestinal lumen, suggesting that worm 5-HT was of host origin. Blood 5-HT level similarly followed luminal increases. It is suggested that the pharmacological action of 5-HT on H. diminuta resulting in worm migration is implemented through the regulation of helminth neuromuscular activity and the carbohydrate metabolism, as has been demonstrated in other parasitic worms.
在腹腔内、肌肉内、皮下和口服给予5-羟色胺（5-HT）后，对大鼠小肠内微小膜壳绦虫的分布变化进行了长达3小时的研究。同时还监测了动脉循环、肠腔和虫体组织中5-HT水平的变化。在给予5-HT后的所有情况下，微小膜壳绦虫均出现向前迁移。迁移程度呈剂量依赖性，剂量越高，迁移反应越明显。感染寄生虫的肠道中正常的5-HT水平高于未感染动物。虫体组织中5-HT水平升高的模式直接跟随肠腔内5-HT水平的升高，这表明虫体的5-HT来源于宿主。血液中的5-HT水平同样跟随肠腔内5-HT水平的升高而升高。有人提出，5-HT对微小膜壳绦虫产生致虫体迁移的药理作用是通过调节蠕虫的神经肌肉活动和碳水化合物代谢来实现的，这一点在其他寄生蠕虫中已得到证实。
