Sukhdeo M V
Department of Animal Sciences, Cook College, Rutgers University, New Brunswick, NJ 08903.
Int J Parasitol. 1992 Sep;22(6):813-7. doi: 10.1016/0020-7519(92)90132-5.
The aim of this study was to determine if intestinal contractions were important in the migration behaviour of the rat tapeworm Hymenolepis diminuta. The objectives were to investigate the intestinal motility responses of the host to a meal which initiates worm migration, and the worms' responses to an artificial peristaltic contraction. A 1 g glucose meal elicited a significant orad migration by H. diminuta in the small intestine of the rat host when compared to water-fed controls (P less than 0.05). The glucose meal also significantly increased the transit rate, and thus, frequency of intestinal contractions in the small intestine of the rat, when compared to water-fed controls (P less than 0.05). Application of a circumintestinal ligature (6.3 g) (simulating an intestinal peristaltic contraction) resulted in significant worm migration when the ligature was applied in regions containing the worm's strobila as compared to controls where loose ligatures were tied in regions containing the strobila, or to controls where tight ligatures were tied ahead of the worm's strobila. These results suggest that H. diminuta migrates in an orad direction in response to the mechanical pressure produced by intestinal contractions induced by host feeding. It is concluded that contractions of the small intestine are an important cue in the migration behaviour of this cestode.
本研究的目的是确定肠道收缩在大鼠绦虫微小膜壳绦虫的迁移行为中是否重要。目标是研究宿主对引发蠕虫迁移的一餐的肠道运动反应，以及蠕虫对人工蠕动收缩的反应。与喂食水的对照组相比，1克葡萄糖餐引发微小膜壳绦虫在大鼠宿主小肠中显著向口腔方向迁移（P小于0.05）。与喂食水的对照组相比，葡萄糖餐还显著提高了大鼠小肠的转运速率，进而提高了小肠收缩频率（P小于0.05）。应用肠周结扎（6.3克）（模拟肠道蠕动收缩），当结扎应用于包含蠕虫节片的区域时，与在包含节片的区域系松散结扎的对照组，或在蠕虫节片前方系紧结扎的对照组相比，导致显著的蠕虫迁移。这些结果表明，微小膜壳绦虫响应宿主进食诱导的肠道收缩产生的机械压力而向口腔方向迁移。结论是小肠收缩是这种绦虫迁移行为的一个重要线索。
