Borderon E, Sillion D, Delplace J, Klifa G
Pathol Biol (Paris). 1984 May;32(5):455-8.
Treatment of bone infections with gentamicin-PMMA beads is an adjunct to conventional surgery. Early failures occurred in a number of cases, due to technical problems, such as incomplete debridement, residual alloplastic material, or gentamicin-resistant pathogens. To evaluate short term results of the method, clinical and bacteriological pre-therapy data were compared with results obtained two and six weeks after surgery, in 25 patients. Gentamicin concentrations, gentamicin levels/MBC for gentamicin, and bactericidal activity in secretions collected from suction drainage were not correlated with outcome. Cultures from the drains were the best parameters: cultures remained positive throughout follow-up in patient with poor clinical results.
用庆大霉素-聚甲基丙烯酸甲酯珠治疗骨感染是传统手术的一种辅助手段。由于技术问题，如清创不彻底、残留异体材料或耐庆大霉素病原体等，许多病例出现早期失败。为评估该方法的短期效果，将25例患者治疗前的临床和细菌学数据与术后两周和六周获得的结果进行了比较。庆大霉素浓度、庆大霉素的最低抑菌浓度倍数以及从负压引流收集的分泌物中的杀菌活性与结果无关。引流物培养是最佳参数：临床结果不佳的患者在整个随访期间培养结果均为阳性。
