Eĭdus L Kh, Korystov Iu N
Radiobiologiia. 1984 May-Jun;24(3):337-40.
A general scheme of modification of reproductive cell death is proposed. At the first, physicochemical, stage modification involves changes in the concentration of thiols and oxygen in a cell. This may be implemented by different agents (e. g. thiols, indolylalkylamines, oxygen, substances influencing the oxygen consumption by a cell, etc.). At the second stage, modification occurs due to the increase (a nonspecific reaction and mitosis delay) or decrease (repair inhibitors and hyperthermia) in the enzymatic repair of potential damages.
提出了生殖细胞死亡修饰的一般方案。在第一个物理化学阶段,修饰涉及细胞中硫醇和氧气浓度的变化。这可以通过不同的试剂(例如硫醇、吲哚烷基胺、氧气、影响细胞耗氧量的物质等)来实现。在第二阶段,修饰是由于潜在损伤的酶促修复增加(非特异性反应和有丝分裂延迟)或减少(修复抑制剂和热疗)而发生的。