[AMP生物合成的腺嘌呤磷酸核糖基转移酶途径中的辐射后紊乱]
[Postradiation disorders in the adenine-phosphoribosyltransferase pathway of AMP biosynthesis].
作者信息
Kuznetsova E V, Koshcheenko N N, Romantsev E F
出版信息
Radiobiologiia. 1984 May-Jun;24(3):347-50.
A study was made of the activity of adenine-phosphoribosyltransferase (EC 2.4.2.7), which catalizes the biosynthesis of AMP from adenine and 5-phospho-alpha-D-riboso-1-diphosphate, in extracts from thymus and liver during 24 h following irradiation of mice in a dose of 245.1 mC/kg (dose-rate of 9.16 X 10(-4)-9.0 X 10(-4) A/kg). Adenine-phosphoribosyltransferase activity of liver remains normal during the entire period of observation. In thymus extracts, the activity of the enzyme decreases down to 70-80% of the control level 3 h after irradiation, it is normalized after 6 h and increases up to 150-160% of the control level by the end of the first day of radiation sickness.
对腺嘌呤磷酸核糖转移酶（EC 2.4.2.7）的活性进行了研究，该酶催化由腺嘌呤和5-磷酸-α-D-核糖-1-二磷酸生物合成AMP。研究对象是在以245.1 mC/kg（剂量率为9.16×10⁻⁴ - 9.0×10⁻⁴ A/kg）的剂量照射小鼠后的24小时内，取自胸腺和肝脏的提取物。在整个观察期内，肝脏中的腺嘌呤磷酸核糖转移酶活性保持正常。在胸腺提取物中，照射后3小时酶活性降至对照水平的70 - 80%，6小时后恢复正常，到放射病第一天结束时增加至对照水平的150 - 160%。
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