Paimela H, Ahonen J, Höckerstedt K, Scheinin T M
Scand J Gastroenterol. 1984 May;19(3):445-8.
The serum concentration of vitamin B12, blood hemoglobin, and gastric acid secretion capacity was studied preoperatively and 1 and 5 years after proximal gastric vagotomy (PGV) in 15 patients. There was a significant reduction in the mean concentration of vitamin B12 at 1 year, but this disappeared within 5 years after PGV. The serum concentration of vitamin B12, however, remained at all times within the health-related reference interval. The blood hemoglobin concentration was unaltered during the follow-up period. The decrease in gastric acid secretion capacity gained by PGV was permanent, and no tendency to increased acidity was observed during the 5-year period. The temporary decrease in serum concentration of vitamin B12 reflects a PGV-induced diminished production of intrinsic factor in the parietal cells. In the characterization of parietal cell function the determination of serum vitamin B12 concentration is, however, much less sensitive than gastric acid secretion tests. The observed change in vitamin B12 concentration after PGV was subclinical, self-corrected, and thus required no treatment.
对15例患者在近端胃迷走神经切断术（PGV）术前、术后1年和5年时的血清维生素B12浓度、血红蛋白及胃酸分泌能力进行了研究。术后1年时维生素B12的平均浓度显著降低，但在PGV术后5年内这种降低消失。然而，血清维生素B12浓度在所有时间均保持在与健康相关的参考区间内。随访期间血红蛋白浓度未改变。PGV导致的胃酸分泌能力下降是永久性的，在5年期间未观察到酸度增加的趋势。血清维生素B12浓度的暂时降低反映了PGV引起的壁细胞内因子产生减少。然而，在壁细胞功能的特征描述中，血清维生素B12浓度的测定比胃酸分泌试验的敏感性要低得多。PGV术后观察到的维生素B12浓度变化是亚临床的、自我纠正的，因此无需治疗。
