Schepp W, Lindstaedt H, Miederer S E, Elster K
Hepatogastroenterology. 1980 Aug;27(4):294-9.
Serum vitamin B12 concentration, parietal cell antibodies (PCA), peak acid output vitamin B12 resorption capacity were determined in 76 patients (age 23 to 82 years). Gastroscopy was performed on all of these patients; guided biopsy was taken from 70 of them. No influence of the inflammatory changes in the gastric mucosa, sex or the presence of PCA on the serum vitamin B12 concentration were demonstrable in our patients, who all revealed a vitamin B12 resorption in the normal range. In particular we were unable to confirm the observation of Döscherholmen et al. (5) of a fall in serum vitamin B12 concentration with increasing age or decreasing PAO. Hence the estimation of the serum vitamin B12 concentration cannot be used as a screening test for selecting those patients suffering from chronic atrophic gastritis and achlorhydria, who should be monitored by gastroscopy and biopsy because of an increased risk of gastric cancer.
对76例患者（年龄23至82岁）测定了血清维生素B12浓度、壁细胞抗体（PCA）、最大胃酸分泌量及维生素B12吸收能力。所有这些患者均接受了胃镜检查；其中70例进行了引导活检。在我们的患者中，未发现胃黏膜炎症变化、性别或PCA的存在对血清维生素B12浓度有影响，所有患者的维生素B12吸收均在正常范围内。特别是我们无法证实Döscherholmen等人（5）的观察结果，即血清维生素B12浓度随年龄增长或最大胃酸分泌量降低而下降。因此，血清维生素B12浓度的测定不能用作筛选患有慢性萎缩性胃炎和胃酸缺乏症患者的检查方法，这些患者因患胃癌风险增加，应通过胃镜检查和活检进行监测。
