Brophy M O, Spring-Mills E J
Scan Electron Microsc. 1984(Pt 1):335-42.
Because of the accumulating evidence that anatomical and physiological changes occur in sites and systems removed from primary tumors, uterine morphology during the development of mammary tumors in C3H/HeJ mice was investigated. C3H/HeJ mice contain the mouse mammary tumor (MTV) virus in their milk and have a high incidence of mammary tumorigenesis. The C3HeB/FeJ mice, used as one set of controls, do not contain the mouse MTV virus in their milk and have a low incidence of mammary tumorigenesis. In young cycling animals without mammary lesions, no differences in uterine morphology were detected between the two strains. However, there were striking differences between the uteri of animals with mammary lesions (C3H/HeJ mice) and the uteri of animals with no mammary lesions. The age-matched control uteri ( 3HeB /FeJ) contained involuted uterine glands and quiescent endometrial stromal and epithelial tissue. The C3H/HeJ mice with mammary tumors contained cystic uterine glands, a stimulated endometrium, and extremely variable endometrial epithelial cells with pleomorphic microvilli. The uterine endometrium from C3H/HeJ mice with preneoplastic lesions also had a stimulated appearance. Some of the uteri of mice with preneoplastic lesions contained cells with cilia or stereocilia. The altered uterine morphology was correlated with preneoplastic and neoplastic mammary lesions and was not related to age or strain differences.
由于越来越多的证据表明，在远离原发性肿瘤的部位和系统中会发生解剖学和生理学变化，因此对C3H/HeJ小鼠乳腺肿瘤发生过程中的子宫形态进行了研究。C3H/HeJ小鼠的乳汁中含有小鼠乳腺肿瘤（MTV）病毒，乳腺肿瘤发生率很高。作为一组对照的C3HeB/FeJ小鼠，其乳汁中不含有小鼠MTV病毒，乳腺肿瘤发生率很低。在没有乳腺病变的年轻性周期动物中，未检测到两种品系之间子宫形态的差异。然而，有乳腺病变的动物（C3H/HeJ小鼠）的子宫与没有乳腺病变的动物的子宫之间存在显著差异。年龄匹配的对照子宫（C3HeB/FeJ）含有退化的子宫腺以及静止的子宫内膜基质和上皮组织。患有乳腺肿瘤的C3H/HeJ小鼠的子宫含有囊性子宫腺、受刺激的子宫内膜以及具有多形性微绒毛的极度可变的子宫内膜上皮细胞。患有肿瘤前病变的C3H/HeJ小鼠的子宫内膜也呈现出受刺激的外观。一些患有肿瘤前病变的小鼠子宫含有带有纤毛或静纤毛的细胞。子宫形态的改变与肿瘤前和肿瘤性乳腺病变相关，与年龄或品系差异无关。
