Nagasawa H, Konishi R, Naito T, Ohmiya S, Mori T
Experimental Animal Research Laboratory, Meiji University, Kanagawa, Japan.
In Vivo. 1987 Jul-Aug;1(4):237-40.
The development and the progression of uterine adenomyosis were compared with those of mammary tumours in four strains of mice with different mammary tumour potentials. Cumulative mammary tumour incidences were the highest and the lowest in SHN and C3H/He, respectively, and intermediate in SLN and GR/A. However, the growth rate of palpable mammary tumours was higher in SHN and SLN than in GR/A and C3H/He, between which no difference was observed. SHN was also higher than SLN in this parameter. While almost all mice bearing mammary tumours developed adenomyosis in all strains, there was an apparent strain-difference in the progression of this lesion which paralleled well that of mammary tumours. All results indicate the intimate relationship between the development and the progression of both lesions in mice.
在四种具有不同乳腺肿瘤发生潜能的小鼠品系中，对子宫腺肌病的发生发展与乳腺肿瘤的发生发展进行了比较。乳腺肿瘤累积发病率在SHN品系中最高，在C3H/He品系中最低，在SLN品系和GR/A品系中处于中间水平。然而，可触及乳腺肿瘤的生长速率在SHN品系和SLN品系中高于GR/A品系和C3H/He品系，后两者之间未观察到差异。在该参数上，SHN品系也高于SLN品系。虽然几乎所有患有乳腺肿瘤的小鼠在所有品系中都发生了腺肌病，但该病变的进展存在明显的品系差异，这与乳腺肿瘤的进展情况高度平行。所有结果表明，在小鼠中这两种病变的发生发展之间存在密切关系。
