Lovén L, Nordström H, Lennquist S
Scand J Plast Reconstr Surg. 1984;18(1):49-53. doi: 10.3109/02844318409057402.
Changes in the calcium- and phosphate homeostasis and its regulating hormones calcitonin (CT) and parathyroid hormone (PTH) are of great importance for several pathophysiological reactions after trauma. In this study calcium, phosphate, CT, PTH and nor-adrenaline, were followed during 14 days after trauma in 20 patients with severe burn injuries. The results showed significantly reduced serum phosphate (S-P) during the first week after trauma, and low ionized calcium fraction (CaF) during the 14 post-traumatic days that were studied. Urinary calcium output was low, about 4.5 mmol/day and urinary phosphate output was as high as 30 mmol/day, despite the low S-P. Plasma nor-adrenaline was elevated with maximum concentrations 6 days after trauma. CT was very high with levels around 1 000 pmol/l after one week. PTH remained within the reference interval, although a statistically significant increase was observed four days after the trauma. The results suggest that the observed changes in calcium- and phosphate homeostasis were related to the humoral response to trauma.
钙磷稳态及其调节激素降钙素（CT）和甲状旁腺激素（PTH）的变化对于创伤后的几种病理生理反应非常重要。在本研究中，对20例严重烧伤患者创伤后14天内的钙、磷、CT、PTH和去甲肾上腺素进行了跟踪观察。结果显示，创伤后第一周血清磷（S-P）显著降低，在所研究的创伤后14天内离子钙分数（CaF）较低。尽管S-P较低，但尿钙排出量较低，约为4.5 mmol/天，而尿磷排出量高达30 mmol/天。血浆去甲肾上腺素升高，创伤后6天浓度最高。一周后CT非常高，水平约为1000 pmol/l。PTH仍在参考区间内，尽管创伤后四天观察到有统计学意义的升高。结果表明，观察到的钙磷稳态变化与对创伤的体液反应有关。
