Robinson C A, Ketchum C H, Grizzle W E, Hall L M, Alexander C B
South Med J. 1984 Jul;77(7):921-3. doi: 10.1097/00007611-198407000-00032.
We have described a patient who had an abnormal isoenzyme of lactate dehydrogenase in both serum and tissue. The presence of LD6 is indicative of a poor prognosis. Some of the biochemical characteristics of the isoenzyme are (1) LD6 is not an artifact, (2) it contains an M subunit but not an H subunit, and (3) it is not an immunoglobulin complex. We believe LD6 may arise during episodes of severe shock as lysosomes rupture and is either a previously sequestered lysosomal LD or is a lysosomal modification of LD5.
我们描述了一位患者，其血清和组织中的乳酸脱氢酶同工酶均异常。LD6的存在表明预后不良。该同工酶的一些生化特性为：（1）LD6不是人为产物；（2）它含有M亚基但不含H亚基；（3）它不是免疫球蛋白复合物。我们认为，LD6可能在严重休克发作期间随着溶酶体破裂而产生，并且要么是先前隔离的溶酶体LD，要么是LD5的溶酶体修饰产物。
