Christenson R H, Scroggs M W, Odom J D
Clin Chem. 1986 Jun;32(6):1234-6.
Histological examination of supraclavicular lymph node tissue obtained at biopsy from a 63-year-old man disclosed metastatic small-cell carcinoma. On admission and for four days subsequently, total lactate dehydrogenase (LD; EC 1.1.1.27) activity in serum was 6.5 times normal; studies of LD isoenzyme showed persistently increased LD-1, with LD-1 greater than LD-2. Isoenzyme electrophoresis of tissue homogenates prepared from the patient's tumor also showed the LD-1 greater than LD-2 pattern. Isoenzyme studies for supraclavicular lymph node tissue from five control subjects showed contrasting isoenzyme patterns as compared with the patients in whom LD-2, LD-3, and LD-4 predominated. Because these abnormalities were persistent, they differ from the temporal sequence for LD usually seen in myocardial infarction. This emphasizes the importance of repetitive sampling for clinical interpretation of data on this enzyme.
对一名63岁男性活检获取的锁骨上淋巴结组织进行组织学检查，发现转移性小细胞癌。入院时及随后四天，血清中总乳酸脱氢酶（LD；EC 1.1.1.27）活性为正常的6.5倍；乳酸脱氢酶同工酶研究显示LD-1持续升高，且LD-1大于LD-2。对患者肿瘤制备的组织匀浆进行同工酶电泳，也显示出LD-1大于LD-2的模式。对五名对照受试者的锁骨上淋巴结组织进行同工酶研究，结果显示与以LD-2、LD-3和LD-4为主的患者相比，同工酶模式不同。由于这些异常持续存在，它们与心肌梗死中通常所见的乳酸脱氢酶时间序列不同。这强调了重复采样对于该酶数据临床解读的重要性。
