Edwards M J, Gray C H, Beatson J
Teratology. 1984 Apr;29(2):305-12. doi: 10.1002/tera.1420290217.
Guinea pigs were exposed to a temperature of 42.5-43.5 degrees C on three occasions between days 20 and 23 of pregnancy. In the first experiment, groups of mothers were exposed at intervals of 18-30 hr. Each exposure ended when the deep rectal temperature had been over 43 degrees C for 6 min and mean temperatures were 43.2-43.4 degrees C. Micrencephaly was found in 78% of heated newborn offspring, the mean brain weights of all groups being significantly less than controls. In the heated groups, the brain weights were reduced significantly as the interval between exposures decreased. Abnormalities other than micrencephaly were found in 10% of heated offspring and included exomphalos, clubfoot, and hypodactyly. In the second experiment, groups of mothers were exposed for 1 hour at intervals of 6-20 hr. The mean temperatures of heated groups were 42.6-42.9 degrees C. The mean brain weights of all groups of heated newborn were significantly reduced and micrencephaly was found in 61% of newborn. Brain weights were reduced significantly as mean maternal temperature increased. There was a significant interaction between the level of temperature elevation and the interval between exposures.(ABSTRACT TRUNCATED AT 250 WORDS)
豚鼠在怀孕第20至23天期间，有三次暴露于42.5 - 43.5摄氏度的环境中。在第一个实验中，每组母鼠每隔18 - 30小时暴露一次。每次暴露在直肠深部温度超过43摄氏度达6分钟且平均温度为43.2 - 43.4摄氏度时结束。在78%的受热新生后代中发现了小头畸形，所有组的平均脑重均显著低于对照组。在受热组中，随着暴露间隔时间的缩短，脑重显著降低。在10%的受热后代中发现了除小头畸形以外的异常情况，包括脐膨出、马蹄内翻足和少趾畸形。在第二个实验中，每组母鼠每隔6 - 20小时暴露1小时。受热组的平均温度为42.6 - 42.9摄氏度。所有受热新生组的平均脑重均显著降低，61%的新生鼠出现小头畸形。随着母体平均温度的升高，脑重显著降低。温度升高水平与暴露间隔时间之间存在显著的交互作用。（摘要截短于250字）
