辐射与热疗对豚鼠产前脑生长迟缓影响的比较。
Comparison of the effects of radiation and hyperthermia on prenatal retardation of brain growth of guinea-pigs.
作者信息
Wanner R A, Edwards M J
出版信息
Br J Radiol. 1983 Jan;56(661):33-9. doi: 10.1259/0007-1285-56-661-33.
On day 21 of pregnancy guinea-pigs were exposed to hyperthermia or gamma radiation. The effects on prenatal growth and especially brain growth of offspring were compared. Doses of 0.04-0.99 Gy of radiation produced a dose-dependent and irreversible reduction of brain weight in the offspring, but had little effect on body weight. Treatment with hyperthermia resulting in maternal temperatures of 41.8-43.9 degrees C after exposure in a heated incubator for an hour also produced a dose-related micrencephaly in the offspring. Comparison of the two agents showed that a dose increment of 0.525 Gy of radiation produced a deficit in brain weight equivalent to an elevation of 1 degree C in maternal temperature. Using this guinea-pig brain weight assay system a threshold was detected of between 0.05 and 0.10 Gy for retardation of brain growth.
在怀孕第21天，豚鼠暴露于高温或伽马辐射下。比较了其对后代产前生长尤其是脑生长的影响。0.04 - 0.99戈瑞的辐射剂量使后代脑重量出现剂量依赖性且不可逆的降低，但对体重影响很小。在加热培养箱中暴露一小时后，母体温度达到41.8 - 43.9摄氏度的高温处理也使后代出现了剂量相关的脑过小畸形。两种因素的比较显示，辐射剂量增加0.525戈瑞所导致的脑重量不足，相当于母体温度升高1摄氏度。利用这个豚鼠脑重量检测系统，检测到脑生长迟缓的阈值在0.05至0.10戈瑞之间。
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