Mohanty D, Hilgard P
Thromb Haemost. 1984 Apr 30;51(2):192-5.
The present work concerns our studies to search for factor(s) which may influence the hemostatic process in or around metastasis of tumours. We studied the platelet aggregating property of a methyl cholanthrene induced experimental tumour. Platelet aggregating material was found to be different from the known aggregating agents like thrombin, ADP, collagen, thromboxane A2 and trypsin. It depends on a critical level of calcium for its action. PAM is a high molecular weight substance which contains sialic acid. It is trypsin and plasmin insensitive. The activity of this substance is not being destroyed by phospholipase-C. Metabolic study indicates that PAM acts by mitochondrial energy metabolic pathway of the platelets.
目前的工作涉及我们寻找可能影响肿瘤转移部位或其周围止血过程的因素的研究。我们研究了甲基胆蒽诱导的实验性肿瘤的血小板聚集特性。发现血小板聚集物质不同于凝血酶、ADP、胶原、血栓素A2和胰蛋白酶等已知的聚集剂。其作用取决于临界钙水平。血小板聚集物质（PAM）是一种含有唾液酸的高分子量物质。它对胰蛋白酶和纤溶酶不敏感。该物质的活性不会被磷脂酶C破坏。代谢研究表明，PAM通过血小板的线粒体能量代谢途径发挥作用。
