4-二甲基氨基苯酚（DMAP）对小鼠、大鼠和豚鼠的急性静脉内和口服毒性及其对血液学变量的影响。

The acute intravenous and oral toxicity in mice, rats and guinea-pigs of 4-dimethylaminophenol (DMAP) and its effects on haematological variables.

作者信息

Marrs T C, Scawin J, Swanston D W

出版信息

Toxicology. 1984 May 14;31(2):165-73. doi: 10.1016/0300-483x(84)90008-8.

Abstract

The single dose oral toxicity of 4- dimethylaminophenol (DMAP) was examined in mice, rats and guinea-pigs and the intravenous toxicity in mice. The oral LD50 in female mice was 946 mg kg-1, in male rats, 780 mg kg-1, in female rats 689 mg kg-1 and in female guinea-pigs 1032 mg kg-1. The intravenous LD50 in female mice was 70 mg kg-1. Dosing with DMAP at the maximum tolerated dose produced Heinz body haemolytic anaemia in rats and Heinz bodies unaccompanied by anaemia in mice. Rats showed biochemical and histological evidence of renal tubular changes.

摘要

对小鼠、大鼠和豚鼠进行了4-二甲基氨基酚（DMAP）的单剂量口服毒性试验，并对小鼠进行了静脉毒性试验。雌性小鼠的口服半数致死量（LD50）为946毫克/千克，雄性大鼠为780毫克/千克，雌性大鼠为689毫克/千克，雌性豚鼠为1032毫克/千克。雌性小鼠的静脉注射LD50为70毫克/千克。以最大耐受剂量给予DMAP会使大鼠产生海因茨小体溶血性贫血，而小鼠则产生无贫血伴随的海因茨小体。大鼠出现了肾小管变化的生化和组织学证据。