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Acute oral toxicity of 4-dimethylaminophenol to the gastrointestinal tract, liver and kidney of the rat.

作者信息

Marrs T C, Bright J E, Swanston D W

出版信息

Arch Toxicol. 1982 May;50(1):89-92. doi: 10.1007/BF00569241.

DOI:10.1007/BF00569241
PMID:7115083
Abstract

Single oral doses up to 25 mg/kg body weight of methaemoglobin-inducing cyanide antidote, 4-dimethylaminophenol (DMAP) did not result in any gross or histological abnormality in the gastrointestinal tract, liver and kidneys of rats killed up to 24 h after the dose. In animals kept for 7 days after the dose to abnormality was observed in the organs examined or in blood samples taken during the course of the experiment.

摘要

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本文引用的文献

1
[On the problem of the expediency of inhalation of amyl nitrite in the therapy of cyanide poisoning].[关于亚硝酸异戊酯吸入疗法在氰化物中毒治疗中的适宜性问题]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1959;237:285-95.
2
[On the value of amyl nitrite in the treatment of hydrocyanic poisoning].[亚硝酸异戊酯在氰化物中毒治疗中的价值]
C R Seances Soc Biol Fil. 1954 Jun;148(11-12):1009-14.
3
Cyanide antidotes and methods of their administration in dogs: a comparative study.犬类氰化物解毒剂及其给药方法：一项比较研究。
Anesthesiology. 1980 Mar;52(3):210-6. doi: 10.1097/00000542-198003000-00004.
4
Formation of ferrihaemoglobin with aminophenols in the human for the treatment of cyanide poisoning.人体中氨基酚与高铁血红蛋白的形成用于治疗氰化物中毒。
Eur J Pharmacol. 1969 Jul;7(1):97-105. doi: 10.1016/0014-2999(69)90170-8.
5
The intracellular and membrane effects of oxidant agents on normal red cells.
Br J Haematol. 1970 Sep;19(3):417-28. doi: 10.1111/j.1365-2141.1970.tb01638.x.
6
Ferrihemoglobin and kidney lesions in rats produced by 4-aminophenol or 4-dimethylaminophenol.4-氨基苯酚或4-二甲基氨基苯酚所致大鼠高铁血红蛋白血症及肾损害
Arch Toxicol. 1975 Dec 18;34(4):337-40. doi: 10.1007/BF00353854.
7
Sodium nitroprusside: pharmacology, toxicology and therapeutics.硝普钠：药理学、毒理学与治疗学
Anesthesiology. 1976 Sep;45(3):340-54.