Adolphs H D, Oehr P
Urol Res. 1984;12(2):125-8. doi: 10.1007/BF00257178.
Plasma concentrations of tissue polypeptide antigen (TPA) were determined in 104 patients with all stages and grades of urinary bladder cancer. Patients with evidence of bacterial or virus infections were excluded. In addition, follow-up controls after treatment were performed. At a rate of 5% false positive values, the diagnostic sensitivity for the tumour stage pTis/pT1 was 63% and for the stages pT2-4 it was 76%. Patients with proved lymph node or distant metastases showed elevated values in 100% of cases. A positive correlation was found between the 3 grades of malignancy and the TPA concentrations. Except for the tumour diagnosis, TPA is a valuable parameter for follow-up controls. Our results show a very good correlation of the plasma TPA concentration with tumour progression as well as with stabilisation and regression after treatment.
对104例处于各阶段和分级的膀胱癌患者测定了血浆组织多肽抗原（TPA）浓度。排除有细菌或病毒感染迹象的患者。此外，还进行了治疗后的随访对照。在假阳性率为5%的情况下，肿瘤分期为pTis/pT1时诊断敏感性为63%，pT2 - 4期时为76%。经证实有淋巴结或远处转移的患者100%显示TPA值升高。在恶性肿瘤的3个分级与TPA浓度之间发现了正相关。除肿瘤诊断外，TPA是随访对照的一个有价值的参数。我们的结果显示血浆TPA浓度与肿瘤进展以及治疗后的稳定和消退有很好的相关性。
