Aliev B M, Vasygova N F, Ivanova E M, Kaverzneva M M
Vopr Onkol. 1984;30(6):41-7.
Radical radiation treatment was given to 152 patients suffering from stage I-III Hodgkin's disease in 1967-1977. Exposure was limited to the lymph collectors above the diaphragm in cases of stage I tumor. Exposure was extended to para-aortal lymph nodes and spleen (or splenic base) in cases of stage II tumor. All three levels were irradiated in cases of stage III. Mean five-year survival rate in the entire group was 89% (stage I-93: IIA-92.8 and IIIA-82.3%); ten-year rate-66.6%. Recurrences were detected in 43.5%; 75% of them were identified within the first two years after radiation. Relapse was more frequent in cases of mixed cell pattern of tumor and lymphoid depletion. Radiation-induced injuries of varying degree were found in 28%, changes in the lungs and soft tissues were prevalent. A relationship between radiation injury frequency and the extent of exposure was established: radiation injury was observed in 4% of stage I cases and in 63% of patients with stage III tumor. Radiation-induced malignancies (breast cancer and fibrosarcoma of ilioinguinal soft tissues) were found in two cases out of 152 at different periods of the study.
1967年至1977年期间，对152例I - III期霍奇金病患者进行了根治性放射治疗。对于I期肿瘤患者，照射范围限于横膈以上的淋巴引流区。对于II期肿瘤患者，照射范围扩大至腹主动脉旁淋巴结和脾脏（或脾门）。对于III期患者，三个区域均接受照射。整个组的平均五年生存率为89%（I期为93%：IIA期为92.8%，IIIA期为82.3%）；十年生存率为66.6%。复发率为43.5%；其中75%在放疗后的头两年内被发现。肿瘤混合细胞型和淋巴细胞耗竭型患者的复发更为频繁。28%的患者出现了不同程度的放射性损伤，肺部和软组织的变化较为普遍。已确定放射性损伤频率与照射范围之间的关系：I期病例中4%出现放射性损伤，III期肿瘤患者中63%出现放射性损伤。在研究的不同阶段，152例患者中有2例出现了放射性诱发的恶性肿瘤（乳腺癌和髂腹股沟软组织纤维肉瘤）。
