Johnson A M
Z Parasitenkd. 1984;70(3):303-9. doi: 10.1007/BF00927816.
The response to an intraperitoneal (i.p.) parasite challenge was compared with that caused by an oral challenge, in five different strains of mice. The results are consistent with the hypothesis that murine susceptibility to toxoplasmosis is route of challenge-dependent as well as strain-dependent. The phenomenon occurs in both sexes and appears to be a recessive trait. The finding that the susceptibility of C57BL/6j mice to oral or i.p. challenge is almost the reverse of that of LACA mice, and that BALB/c mice are resistant to challenge by either route, offers an excellent laboratory model for studies on susceptibility to toxoplasmosis.
在五种不同品系的小鼠中，比较了腹腔内（i.p.）寄生虫攻击与口服攻击所引起的反应。结果与以下假设一致：小鼠对弓形虫病的易感性不仅取决于品系，还取决于攻击途径。这种现象在两性中均会出现，并且似乎是一种隐性性状。C57BL/6j小鼠对口服或腹腔内攻击的易感性几乎与LACA小鼠相反，以及BALB/c小鼠对两种途径的攻击均具有抗性，这一发现为研究对弓形虫病的易感性提供了一个出色的实验室模型。
