Neĭmark I I, Timoshnikov V M
Probl Endokrinol (Mosk). 1978 May-Jun;24(3):28-32.
The authors analysed the data obtained in examination of 106 patients with carcinoma of the thyroid gland residing in the Mountaineous-Altai region endemic by goiter. A conclusion was drawn that in the great majority of the aforesaid patients an important etiological factor in the development of malignant tumour was nodular and diffuse-nodular goiter. In patients with carcinoma of the thyroid gland residing the mentioned region the blood iodine, cobalt, and copper content was much greater than in healthy persons. Iodine concentration in the tumour tissue of the thyroid gland was diminished, and of copper and cobalt--increased in comparison with such in healthy tissue. Blood iodine content in patients with carcinoma, and iodine in the tumour tissue of the thyroid gland was much less, and of copper and cobalt--increased in comparison with such in patients with endemic goiter. Deficiency of trace elements (iodine, copper, cobalt) in the surrounding environment of the endemic regions of the Mountaneous-Altai and the change of their content in the organism of patients with carcinoma of the thyroid gland permitted to refer this disease to geographical pathology.
作者分析了对居住在阿尔泰山地区甲状腺肿流行区的106例甲状腺癌患者检查所获得的数据。得出的结论是，在上述大多数患者中，恶性肿瘤发生的一个重要病因是结节性和弥漫性结节性甲状腺肿。在居住于上述地区的甲状腺癌患者中，血液中碘、钴和铜的含量远高于健康人。与健康组织相比，甲状腺肿瘤组织中的碘浓度降低，而铜和钴的浓度升高。与地方性甲状腺肿患者相比，甲状腺癌患者血液中的碘含量以及甲状腺肿瘤组织中的碘含量要少得多，而铜和钴的含量则升高。阿尔泰山地区地方性病区周围环境中微量元素（碘、铜、钴）的缺乏以及甲状腺癌患者机体中这些元素含量的变化，使得这种疾病可被归为地理病理学范畴。
